Statut
Thématiques de recherche
I am an ambitious PhD student aiming to develop a career in research. I am currently interested in learning to develop integrative projects that approach a question from different angles to reach a robust answer. I am in the third year of my PhD, supervised by Dr. Guillermo BARRETO in the lab EPIGLYCAN. We are currently working in elucidating the epigenetic mechanisms in the development of lung diseases.
Epigenetic Transcription Regulation in Idiopathic Pulmonary Fibrosis
This project aims to elucidate the role of the RNA-binding protein FUS (Fused in Sarcoma) in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We will perform integrative multi-omics analyses on primary lung fibroblasts from IPF patients and healthy donors to investigate how FUS interacts with the MiCEE complex, regulatory non-coding RNAs, histone modifications to influence expression. The functional relevance of FUS-dependent mechanisms will be validated in human precision-cut lung slices (hPCLS). Furthermore, we will explore how FUS contributes in fibrotic contexts. Together, these studies aim to define the molecular role of FUS in IPF, providing insights that may guide the development of mechanism-based therapeutic strategies.
Selected publications
[7] Cordero, J. Swaminathan, G. Rogel-Ayala, D.G. Rubio, K. Elsherbiny, A. Mahmod, S. Szymanski,
W, Graumann, J. Braun, T. Günther, S. Dobreva, G. Barreto, G. Nuclear microRNA 9 mediates Gquadruplex formation and 3D genome organization during TGF-β-induced transcription. Nature
communications 15, 10711; 2024. https://doi.org/10.1038/s41467-024-54740-x (IF 14.7)
[6] Swaminathan, G.; Rogel-Ayala, D.G.; Armich, A.; Barreto, G. Implications in Cancer of Nuclear
Micro RNAs, Long Non-Coding RNAs, and Circular RNAs Bound by PRC2 and FUS. Cancers 2024,
16, 868. https://doi.org/10.3390/cancers16050868 (IF 5.2)
[5] Rubio, K. Romero-Olmedo, A.J. Pouya, S. Swaminathan, G. Ranvir, V.P. Rogel-Ayala, D.G.
Cordero, J. Günther, S. Metha, A. Bassaly, B. Braubach, P. Wygrecka, M. Gattenlöhner, S. Tresch, A.
Braun, T. Dobreva, G. Rivera, M.N. Singh, I, Graumann, J. Barreto, G. Non-canonical integrin signaling activates EGFR and RAS-MAPK-ERK signaling in small cell lung cancer. Theranostics, 13(8), 2384-
2407. https://doi.org/10.7150/thno.79493 (IF 12.4).
[4] Rubio, K.; Hernández-Cruz, E.Y. Rogel-Ayala, D.G. Sarvari, P. Isidoro, C. Barreto, G. PedrazaChaverri, J. Nutriepigenomics in Environmental-Associated Oxidative Stress. Antioxidants 2023, 12, 771. https://doi.org/10.3390/antiox12030771 (IF 7.675).
[3] Rogel-Ayala, D.G. Muñoz-Medina, J.E. Vicente-Juárez, V.D. Grether-González, P. Morales-Barquet,
D.A. Martínez-García, A.d.J. Echaniz-Aviles, M.O.L. Sevilla-Montoya, R. Martínez-Juárez, A. ArtegaVázquez, J. Ángeles-Martínez, J. Vargas-Alarcón, G. Hidalgo-Bravo, A. Monroy-Muñoz, I.E.Association of the EPAS1 rs7557402 Polymorphism with Hemodynamically Significant Patent Ductus Arteriosus Closure Failure in Premature Newborns under Pharmacological Treatment with Ibuprofen. Diagnostics
2023, 13, 2558. https://doi.org/10.3390/diagnostics13152558 (IF 3.411).
[2] Aguinaga-Ríos, M. Valdespino-Vázquez, M.Y. Medina-Castro, D. Espino-Sosa, S. Sevilla-Montolla,
R. Miranda-Araujo, O. Acevedo-Gallegos, S. Monroy-Muñoz, I.E. Helguera-Reppeto, A.C. Pérez-Durán,
J. Mariscal-Mendizabal, L.F. Franco-Murillo, M. R. Lara-Enríquez R.M. Armijos-Torres, J.C. RogelAyala, D.G. Cardona-Pérez. J.A. (2021) Causal analysis of fetal death in high-risk pregnancies. Journal of Perinatal Medicine; 49(6), 740-747. https://doi.org/10.1515/jpm-2020-0352 (IF 1.901).
[1] Morales-Avila, E. Ferro-Flores, G. Ocampo-García, B.E. López-Téllez, G. López-Ortega, J. RogelAyala, D.G. Sánchez-Padilla, D. (2017). Antibacterial Efficacy of Gold and Silver Nanoparticles
Functionalized with the Ubiquicidin (29–41) Antimicrobial Peptide. Journal of Nanomaterials, vol. 2017, Article ID 5831959. https://doi.org/10.1155/2017/5831959 (IF 2.233).
Responsabilités
Analyze and integrate experimental data across multiple omics layers, including transcriptomics, proteomics, and epigenomics.
Support the preparation of scientific documents such as manuscripts, conference abstracts, and project reports.
Engage actively in scientific discussions within the research team and with external collaborators.
