FEFER-REACT-EU
Duration: 2021-2023
Total European funding: €1,780,582
Coordinator: Xavier Manival
Projet : MolAI4Cryo, Modeling and Artificial Intelligence for Cryo-EM 3D structures to fight COVID
The aim of MolAI4Cryo is to decipher the interaction between coronavirus proteins and the host’s cellular messenger RNA splicing machinery in order to propose new antiviral targets for therapeutic purposes in the fight against COVID-19. This project will also enable us to improve our understanding of the mechanisms of viral infection of the cell and its longer-term impact.
This project involved setting up a Cryo-Microscopy platform, including the purchase of a Glacios 2 microscope and a Vitrobot.
PARTNERS
IMoPA
UAR 2008 IBSLor
FEDER-FSE Lorraine et Massif des Vosges 2014-20
Duration: 2014-2020
Total European funding: €298,500
Coordinator: David Moulin
Projet : TARGET Translational research in Articular and Gastrointestinal inflammatory diseases in Grand-EsT
In 2014, the ERDF awarded a grant of €298,500 to the TARGET Translational research in Articular and Gastrointestinal inflammatory diseases in Grand-EsT project. This project is co-financed by the European Union as part of the FEDER-FSE Lorraine et Massif des Vosges 2014-2020 Operational Programme.
The aim of this project is to identify molecular/cellular signatures reflecting the pathophysiological mechanisms of chronic inflammatory bowel disease (IBD) and chronic inflammatory rheumatism (CIR), and/or to assess sensitivity or non-response to biotherapies.
This project required the acquisition of a state-of-the-art conventional cytometer: the BD FACSymphony A3. This is a powerful analytical tool that enables users to identify and analyse distinctive phenotypes in heterogeneous populations. It makes full use of advances in instrumentation, fluorochrome development and bioinformatics. Featuring 5 lasers with 28 colour parameters, it is dedicated to complex multi-parametric studies.
The most sensitive and rapid system on the market, it enables users to search for rare events. The equipment can be configured to use different wavelengths and traditional and/or unique powers.
Specific features:
Diffusion performance is optimised for the resolution of lymphocytes, monocytes and granulocytes.
It offers the possibility of analysing a whole range of phenotypes and of interrogating cellular subsets very precisely.
Its high resolution allows the separation of fixed platelets; 0.3 μm beads; 0.1 μm fluorescent beads from electronic noise.
